News Feed

Midwest Clinical Research Center Participates in Bringing New Non-Opioid Pain Control Medicine to the Market

MCRC was one of the sites that participated in hernia repair studies, investigating a non-opioid postoperative pain medicine. The sponsor, Heron Therapeutics, has announced positive topline results from its completed Phase 3 studies of the investigational agent HTX-011 in subjects undergoing bunionectomy and hernia repair, which achieved all primary and key secondary endpoints in both Phase 3 trials, demonstrating statistically significant reductions in both pain intensity and the use of opioid rescue medications through 72 hours following surgery.

CLICK HERE to read about the positive topline results from the Phase 3 clinical trial.

I Want To Volunteer!

About Midwest Clinical Research Center

Since 2002, Midwest Clinical Research Center (MCRC) has been dedicated to working with sponsors and volunteer subjects to test and develop new medication therapies for psychiatric conditions. The clinical trials we conduct at our outpatient and inpatient sites provide data for the effectiveness and safety of new medications for the treatment of Depression, Schizophrenia, Bipolar disorder, and more.

MCRC has a caring, professional staff of Board certified Psychiatrists, nurses, psychologists, and study coordinators who are dedicated to answering all of your questions about study participation. Our staff is highly trained in conducting clinical trials that comply with all Federal, State and GCP/ICH guidelines, thus ensuring the collection of exceptional quality data, safety of volunteer subjects and superior care.


Midwest Clinical Research Center (MCRC) is the only site in Dayton, Ohio that is dedicated to conducting CNS clinical trials. The clinic has a strong reputation for enrolling the right subjects and providing sponsors with good, clean, quality data in a timely manner. The staff is well trained to conduct complex studies and all raters have consistently met expectations set by sponsors.

Midwest Clinical Research Center is a dedicated inpatient and outpatient research facility centrally located within a large medical campus. The location affords wide visibility to potential patients, physicians, and other ancillary healthcare providers. It is also less than 2 miles from a hospital with full emergency medical services. The research site includes a 15-bed ward, dedicated for inpatient and clinical pharmacology research studies equipped with high speed internet and other amenities designed to ensure patient comfort.


Dr. Bernadette D’Souza

Bernadette D’Souza, MD, is the Medical Director for Midwest Clinical Research Center in Dayton, Ohio. The center was established in 2002 by Dr. D’Souza for the purpose of conducting clinical research trials in psychiatric conditions. Since then, Dr. D’Souza has functioned as the Principal Investigator on more than 200 clinical studies, including research trials in Addiction, Alzheimer’s Disease, Attention Deficit Hyperactivity Disorder, Binge Eating Disorder, Bipolar Disorder, Depression, Fibromyalgia & Pain, Anxiety Disorders, Insomnia, Post Traumatic Stress Disorder, Sexual Dysfunction, Schizophrenia, Stuttering, and Smoking Cessation.

Dr. D’Souza is a Certified Physician Investigator through the Association of Clinical Research Professionals. In addition, she is a staff physician at Good Samaritan Hospital in Dayton, Ohio. Dr. D’Souza is board certified in Psychiatry by the American Board of Psychiatry and Neurology, and previously served as an examiner for the Ohio Board of Psychiatry. As a researcher, Dr. D’Souza has been an investigator on clinical trials sponsored by major pharmaceutical companies as well as the National Institute of Mental Health.

Dr. Otto Dueno

Dr. Otto Dueno joined Midwest Clinical Research Center in 2011. He has served as Principal Investigator or Sub Investigator on 65 clinical trials for Addiction, Attention Deficit Hyperactivity Disorder, Binge Eating Disorder, Bipolar Disorder, Depression, Fibromyalgia, Generalized Anxiety Disorder, Obsessive Compulsive Disorder, Post Traumatic Stress Disorder, Schizophrenia, Smoking Cessation, and Tardive Dyskinesia.

Dr. Dueno received his medical degree from Universidad Central del Caribe School of Medicine in Puerto Rico and completed his residency in Psychiatry at The Ohio State University. He is board certified by the ABPN and has been in private practice in the Dayton area since 1996.