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St. Louis Clinical Trials Participates in Bringing New Non-Opioid Pain Control Medicine to the Market

SLCT was one of the sites that participated in hernia repair studies, investigating a non-opioid postoperative pain medicine. The sponsor, Heron Therapeutics, has announced positive topline results from its completed Phase 3 studies of the investigational agent HTX-011 in subjects undergoing bunionectomy and hernia repair, which achieved all primary and key secondary endpoints in both Phase 3 trials, demonstrating statistically significant reductions in both pain intensity and the use of opioid rescue medications through 72 hours following surgery.

CLICK HERE to read about the positive topline results from the Phase 3 clinical trial.

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St. Louis Clinical Trials is a free standing medical research facility located in west St. Louis that is easily accessible by most major highways.  There is no charge for parking for those individuals who choose to drive.  Study participants who are unable to drive are offered transportation free of charge. Studies at this location may sometimes require overnight stays. In order to make those stays comfortable we provide many amenities including video games, internet access, cable television, exercise area, game room, as well as a smoking area (for studies that permit smoking). We offer nutritious, well-balanced meals served by a local catering company.

St. Louis Clinical Trials is proven and trusted resource for the conduct of studies in Schizophrenia, Major Depressive Disorder, Bipolar Mania, Alzheimer’s disease, Addiction and Pain Management.

  • Free Parking or Transportation
  • Comfortable Accommodations
  • Catered Meals
  • Recreational Facilities
  • Computer Access with Wi-Fi
  • Experienced, Friendly Staff


A private, inpatient and outpatient research facility, St. Louis Clinical Trials is focused in Phase I-III clinical trials in a variety of CNS indications. The purpose built, 30-bed facility is fully equipped, secure, locked and supported by highly experienced MDs, DOs, Nurse Practitioners, Psychologist, Paramedics, Patient Care Technicians, CRCs, Registered Pharmacists (PharmD), Laboratory Technicians and Regulatory Specialists. The facility is built for the comfort of research subjects who have access to an exercise area, TV, video games, internet access, game room and other amenities.

The facility maintains a compounding pharmacy with an enclosed HEPA filter hood; a double-locked, limited access drug storage room with a 24-hour monitoring system; an IATA and CLIA certified processing laboratory; and -20 and -70 degree sample storage. ECGs are performed at the clinic and radiology facilities (x-ray, PET, CT,MRI, fMRI) are located nearby. The research clinic has dedicated monitor rooms with high-speed internet for remote data entry access, on-site long-term storage, a conference room, lobby waiting area and free parking. A central IRB is utilized for all regulatory submissions.


Dr. Daniel Gruener

Daniel Gruener, MD, is board certified by the American Academy of Psychiatry and Neurology as well as by the America Academy of Pain Management. He has conducted more than 250 clinical trials in Pain, Addiction, Opioid Induced Constipation, Schizophrenia, Bipolar, Depression, Anxiety, Sleep Disorders, Alzheimer’s Disease, Hepatitis B & C, Diabetes and Smoking Cessation. Dr. Gruener has been a thought leader in pain for more than 20 years and has served as a board member of the American Pain Society. Additionally, he has written several books, most significant, he co-authored a textbook on pain and is the senior editor for Pain Control in the Primary Care Setting, published by the APS, which was the standard of care for several years.